White matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology.

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TitleWhite matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology.
Publication TypeJournal Article
Year of Publication2015
AuthorsRoalf, DR, Gur, RE, Verma, R, Parker, WA, Quarmley, M, Ruparel, K, Gur, RC
JournalSchizophr Res
Volume161
Issue1
Pagination42-9
Date Published2015 Jan
ISSN1573-2509
KeywordsAdult, Anisotropy, Cognition Disorders, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nerve Fibers, Myelinated, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, White Matter
Abstract

BACKGROUND: Diffusion tensor imaging (DTI) studies in schizophrenia report widespread aberrations in brain white matter (WM). These appear related to poorer neurocognitive performance and higher levels of negative and positive symptomatology. However, identification of the most salient WM aberrations to neurocognition and clinical symptoms is limited by relatively small samples with divergent results.METHODS: We examined 53 well-characterized patients with schizophrenia and 62 healthy controls. All participants were administered a computerized neurocognitive battery, which evaluated performance in several domains. Patients were assessed for negative and positive symptoms. Fractional anisotropy (FA) of WM cortical regions and WM fiber tracts were compared across the groups. FA values were also used to predict neurocognitive performance and symptoms.RESULTS: We confirm widespread aberrant WM microstructure in a relatively large sample of well-characterized patients with schizophrenia in comparison to healthy participants. Moreover, we illustrate the utility of FA measures in predicting global neurocognitive performance in healthy participants and schizophrenia patients, especially for reaction time. FA was less predictive of clinical symptomatology.CONCLUSIONS: Using a standardized computerized neurocognitive battery and diffusion tensor imaging we show that behavioral performance is moderated by a particular constellation of WM microstructure in healthy individuals that differs in schizophrenia.

DOI10.1016/j.schres.2014.09.026
Alternate JournalSchizophr. Res.
PubMed ID25445621
PubMed Central IDPMC4410368
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
R01 MH060722 / MH / NIMH NIH HHS / United States
R01 MH084856 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
R01MH084856 / MH / NIMH NIH HHS / United States
R01 MH042191 / MH / NIMH NIH HHS / United States