Using standardized diagnostic instruments to classify children with autism in the study to explore early development.

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TitleUsing standardized diagnostic instruments to classify children with autism in the study to explore early development.
Publication TypeJournal Article
Year of Publication2015
AuthorsWiggins, LD, Reynolds, A, Rice, CE, Moody, EJ, Bernal, P, Blaskey, L, Rosenberg, SA, Lee, L-C, Levy, SE
JournalJ Autism Dev Disord
Volume45
Issue5
Pagination1271-80
Date Published2015 May
ISSN1573-3432
KeywordsAlgorithms, Case-Control Studies, Child, Child Development, Child Development Disorders, Pervasive, Child, Preschool, Compulsive Behavior, Female, Humans, Male, Psychiatric Status Rating Scales, Psychometrics
Abstract

The Study to Explore Early Development (SEED) is a multi-site case-control study designed to explore the relationship between autism spectrum disorder (ASD) phenotypes and etiologies. The goals of this paper are to (1) describe the SEED algorithm that uses the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) to classify children with ASD, (2) examine psychometric properties of different ASD classification methods, including the SEED method that incorporates rules for resolving ADI-R and ADOS discordance, and (3) determine whether restricted interests and repetitive behaviors were noted for children who had instrument discordance resolved using ADI-R social and communication scores. Results support the utility of SEED criteria when well-defined groups of children are an important clinical or research outcome.

DOI10.1007/s10803-014-2287-3
Alternate JournalJ Autism Dev Disord
PubMed ID25348175
PubMed Central IDPMC4486213
Grant ListU10 DD000180 / DD / NCBDD CDC HHS / United States
U10DD000184 / DD / NCBDD CDC HHS / United States
U10 DD000181 / DD / NCBDD CDC HHS / United States
U10DD000181 / DD / NCBDD CDC HHS / United States
U10 DD000184 / DD / NCBDD CDC HHS / United States
U01 DD001210 / DD / NCBDD CDC HHS / United States
U01 DD000498 / DD / NCBDD CDC HHS / United States
CC999999 / / Intramural CDC HHS / United States
U10DD000182 / DD / NCBDD CDC HHS / United States
U10 DD000182 / DD / NCBDD CDC HHS / United States
U10DD000498 / DD / NCBDD CDC HHS / United States
U10DD000183 / DD / NCBDD CDC HHS / United States
U10 DD000183 / DD / NCBDD CDC HHS / United States
U10DD000180 / DD / NCBDD CDC HHS / United States
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