Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy.

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TitleThree-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy.
Publication TypeJournal Article
Year of Publication2017
AuthorsThawani, JP, Singh, N, Pisapia, JM, Abdullah, KG, Parker, D, Pukenas, BA, Zager, EL, Verma, R, Brem, S
JournalNeurosurgery
Volume80
Issue4
Pagination635-645
Date Published2017 Apr 01
ISSN1524-4040
KeywordsBrain, Brain Neoplasms, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Glioma, Humans, Models, Anatomic, Neurosurgical Procedures, Printing, Three-Dimensional, White Matter
Abstract

BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain.

OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy.

METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques.

RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution.

CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.

DOI10.1093/neuros/nyx009
Alternate JournalNeurosurgery
PubMed ID28362934