|Title||Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Thawani, JP, Singh, N, Pisapia, JM, Abdullah, KG, Parker, D, Pukenas, BA, Zager, EL, Verma, R, Brem, S|
|Date Published||2017 Apr 01|
|Keywords||Brain, Brain Neoplasms, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Glioma, Humans, Models, Anatomic, Neurosurgical Procedures, Printing, Three-Dimensional, White Matter|
BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain.
OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy.
METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques.
RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution.
CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.