Three diagnostic approaches to Asperger syndrome: implications for research.

We just began a large new study on
Autism, ADHD, Anxiety & Depression in 12-17 year-olds.
Read more and learn how you can help!

TitleThree diagnostic approaches to Asperger syndrome: implications for research.
Publication TypeJournal Article
Year of Publication2005
AuthorsKlin, A, Pauls, D, Schultz, R, Volkmar, F
JournalJ Autism Dev Disord
Date Published2005 Apr
KeywordsAdolescent, Adult, Asperger Syndrome, Autistic Disorder, Child, Cognition Disorders, Comorbidity, Diagnosis, Differential, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Intellectual Disability, Interview, Psychological, Male, Speech Disorders

OBJECTIVE: To examine the implications for research of the use of three alternative definitions for Asperger syndrome (AS). Differences across the three nosologic systems were examined in terms of diagnostic assignment, IQ profiles, comorbid symptoms, and familial aggregation of social and other psychiatric symptoms.METHOD: Standard data on diagnosis, intellectual functioning, comorbidity patterns, and family history were obtained on 65 individuals screened for a very high probability of having autism without mental retardation (or higher functioning autism, HFA) or AS. Diagnoses of AS were established based on three different approaches: DSM-IV, presence/absence of communicative phrase speech by 3 years, and a system designed to highlight prototypical features of AS.RESULTS: Agreement between the three diagnostic systems was poor. AS could be differentiated from HFA (but not from PDD-NOS) on the basis of IQ profiles in two of the three systems. Differences in patterns of comorbid symptomatology were obtained in two of the three systems, although differences were primarily driven by the PDD-NOS category. Only one of the approaches yielded differences relative to aggregation of the "broader phenotype" in family members.CONCLUSIONS: Diagnostic assignments of AS based on three commonly used approaches have low agreement and lead to different results in comparisons of IQ profiles, patterns of comorbidity, and familial aggregation of psychiatric symptoms across the approach-specific resultant groups of HFA, AS, and PDD-NOS.

Alternate JournalJ Autism Dev Disord
PubMed ID15909408
Grant ListP01 HD 03008 / HD / NICHD NIH HHS / United States
P01 HD/DC35482 / HD / NICHD NIH HHS / United States