Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008).

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TitleSocial behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: theoretical comment on McNaughton et al. (2008).
Publication TypeJournal Article
Year of Publication2008
AuthorsBrodkin, ES
JournalBehav Neurosci
Volume122
Issue2
Pagination483-9
Date Published2008 Apr
ISSN0735-7044
KeywordsAnimals, Autistic Disorder, Disease Models, Animal, Female, Fragile X Mental Retardation Protein, Fragile X Syndrome, Humans, Male, Mice, Mice, Knockout, Phenotype, Social Behavior
Abstract

Comments on the article by C. H. McNaughton et al.. Individuals with fragile X syndrome (FXS) show varying degrees of social behavior disturbances, from social anxiety to autism. This variability of social behavior phenotypes in FXS is likely to be due to interactions of Fmr1 with other gene variants and environmental factors during brain development, although very little is known about the specific genetic and neural mechanisms involved. The Fmr1 knockout mouse is an important experimental resource for elucidating the neural mechanisms of social anxiety, social reward, and social cognition. However, studies of social behavior phenotypes in the Fmr1 knockout mouse are still in early stages. McNaughton et al provide important new information on these phenotypes in the Fmr1 knockout mouse through their use of novel, detailed behavioral analysis to identify signs of increased social anxiety and social cognition deficits. Their significant refinements in measurement of social behavior phenotypes will help to advance future efforts to elucidate the genetic and neural mechanisms underlying social behavior disturbances in FXS and autism.

DOI10.1037/0735-7044.122.2.483
Alternate JournalBehav. Neurosci.
PubMed ID18410188
Grant ListK08MH068586 / MH / NIMH NIH HHS / United States
R01MH080718 / MH / NIMH NIH HHS / United States
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