Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory.

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TitleSleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory.
Publication TypeJournal Article
Year of Publication2014
AuthorsPrince, T-M, Wimmer, M, Choi, J, Havekes, R, Aton, S, Abel, T
JournalNeurobiol Learn Mem
Volume109
Pagination122-30
Date Published2014 Mar
ISSN1095-9564
KeywordsAnimals, Hippocampus, Long-Term Potentiation, Male, Memory, Long-Term, Mice, Mice, Inbred C57BL, Recognition (Psychology), Sleep Deprivation, Space Perception, Time Factors
Abstract

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3h of sleep deprivation significantly impaired memory when deprivation began 1h after training. In contrast, 3 h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function.

DOI10.1016/j.nlm.2013.11.021
Alternate JournalNeurobiol Learn Mem
PubMed ID24380868
PubMed Central IDPMC3966473
Grant ListT32 HL007953 / HL / NHLBI NIH HHS / United States
T32HL007953 / HL / NHLBI NIH HHS / United States
K99 EY021503 / EY / NEI NIH HHS / United States
K12 GM081259 / GM / NIGMS NIH HHS / United States
DP2 MH104119 / MH / NIMH NIH HHS / United States
P01AG017628 / AG / NIA NIH HHS / United States
T32 GM007517 / GM / NIGMS NIH HHS / United States
P01 AG017628 / AG / NIA NIH HHS / United States
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