Short-range connections in the developmental connectome during typical and atypical brain maturation.

Registration Now Open for

ADOS-2 Clinical Training Workshop

November 25-27. Click here for info!

TitleShort-range connections in the developmental connectome during typical and atypical brain maturation.
Publication TypeJournal Article
Year of Publication2017
AuthorsOuyang, M, Kang, H, Detre, JA, Roberts, TPL, Huang, H
JournalNeurosci Biobehav Rev
Volume83
Pagination109-122
Date Published2017 Dec
ISSN1873-7528
Abstract

The human brain is remarkably complex with connectivity constituting its basic organizing principle. Although long-range connectivity has been focused on in most research, short-range connectivity is characterized by unique and spatiotemporally heterogeneous dynamics from infancy to adulthood. Alterations in the maturational dynamics of short-range connectivity has been associated with neuropsychiatric disorders, such as autism and schizophrenia. Recent advances in neuroimaging techniques, especially diffusion magnetic resonance imaging (dMRI), resting-state functional MRI (rs-fMRI), electroencephalography (EEG) and magnetoencephalography (MEG), have made quantification of short-range connectivity possible in pediatric populations. This review summarizes findings on the development of short-range functional and structural connections at the macroscale. These findings suggest an inverted U-shaped pattern of maturation from primary to higher-order brain regions, and possible "hyper-" and "hypo-" short-range connections in autism and schizophrenia, respectively. The precisely balanced short- and long-range connections contribute to the integration and segregation of the connectome during development. The mechanistic relationship among short-range connectivity maturation, the developmental connectome and emerging brain functions needs further investigation, including the refinement of methodological approaches.

DOI10.1016/j.neubiorev.2017.10.007
Alternate JournalNeurosci Biobehav Rev
PubMed ID29024679
PubMed Central IDPMC5730465
Grant ListP41 EB015893 / EB / NIBIB NIH HHS / United States
R01 DC008871 / DC / NIDCD NIH HHS / United States
R01 MH092535 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States