Sex differences in the structural connectome of the human brain.

Registration Now Open for

ADOS-2 Clinical Training Workshop

November 25-27. Click here for info!

TitleSex differences in the structural connectome of the human brain.
Publication TypeJournal Article
Year of Publication2014
AuthorsIngalhalikar, M, Smith, A, Parker, D, Satterthwaite, TD, Elliott, MA, Ruparel, K, Hakonarson, H, Gur, RE, Gur, RC, Verma, R
JournalProc Natl Acad Sci U S A
Volume111
Issue2
Pagination823-8
Date Published2014 Jan 14
ISSN1091-6490
KeywordsAdolescent, Brain, Child, Connectome, Diffusion Tensor Imaging, Female, Humans, Linear Models, Male, Sex Characteristics, Young Adult
Abstract

Sex differences in human behavior show adaptive complementarity: Males have better motor and spatial abilities, whereas females have superior memory and social cognition skills. Studies also show sex differences in human brains but do not explain this complementarity. In this work, we modeled the structural connectome using diffusion tensor imaging in a sample of 949 youths (aged 8-22 y, 428 males and 521 females) and discovered unique sex differences in brain connectivity during the course of development. Connection-wise statistical analysis, as well as analysis of regional and global network measures, presented a comprehensive description of network characteristics. In all supratentorial regions, males had greater within-hemispheric connectivity, as well as enhanced modularity and transitivity, whereas between-hemispheric connectivity and cross-module participation predominated in females. However, this effect was reversed in the cerebellar connections. Analysis of these changes developmentally demonstrated differences in trajectory between males and females mainly in adolescence and in adulthood. Overall, the results suggest that male brains are structured to facilitate connectivity between perception and coordinated action, whereas female brains are designed to facilitate communication between analytical and intuitive processing modes.

DOI10.1073/pnas.1316909110
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID24297904
PubMed Central IDPMC3896179
Grant ListR01 MH092862 / MH / NIMH NIH HHS / United States
MH089924 / MH / NIMH NIH HHS / United States
MH092862 / MH / NIMH NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K23MH098130 / MH / NIMH NIH HHS / United States
MH089983 / MH / NIMH NIH HHS / United States
R01 MH079938 / MH / NIMH NIH HHS / United States
MH079938 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States
Comments
Leave a Comment