Sex Differences in Autism: Examining Intrinsic and Extrinsic Factors in Children and Adolescents Enrolled in a National ASD Cohort.

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TitleSex Differences in Autism: Examining Intrinsic and Extrinsic Factors in Children and Adolescents Enrolled in a National ASD Cohort.
Publication TypeJournal Article
Year of Publication2021
AuthorsDillon, EF, Kanne, S, Landa, RJ, Annett, R, Bernier, R, Bradley, C, Carpenter, L, Kim, SHyun, Parish-Morris, J, Schultz, R, Wodka, EL
Corporate AuthorsConsortium, SPARK
JournalJ Autism Dev Disord
Date Published2021 Dec 02
ISSN1573-3432
Abstract

Discernment of possible sex-based variations in presentations of autism spectrum disorder (ASD) symptoms is limited by smaller female samples with ASD and confounds with ASD ascertainment. A large national cohort of individuals with autism, SPARK, allowed parent report data to be leveraged to examine whether intrinsic child characteristics and extrinsic factors differentially impact males and females with ASD. Small but consistent sex differences in individuals with ASD emerged related to both intrinsic and extrinsic factors, with different markers for males and females. Language concerns in males may make discernment of ASD more straightforward, while early motor concerns in females may hamper diagnosis as such delays are not identified within traditional ASD diagnostic criteria.

DOI10.1007/s10803-021-05385-y
Alternate JournalJ Autism Dev Disord
PubMed ID34859339
Grant List534041 / / Simons Foundation /