Repetitive behavior in 12-month-olds later classified with autism spectrum disorder.

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TitleRepetitive behavior in 12-month-olds later classified with autism spectrum disorder.
Publication TypeJournal Article
Year of Publication2014
AuthorsElison, JT, Wolff, JJ, J Reznick, S, Botteron, KN, Estes, AM, Gu, H, Hazlett, HC, Meadows, AJ, Paterson, SJ, Zwaigenbaum, L, Piven, J
Corporate AuthorsInfant Brain Imaging Study (IBIS) Network
JournalJ Am Acad Child Adolesc Psychiatry
Volume53
Issue11
Pagination1216-24
Date Published2014 Nov
ISSN1527-5418
KeywordsChild Development Disorders, Pervasive, Cohort Studies, Female, Genetic Predisposition to Disease, Humans, Infant, Longitudinal Studies, Male, Prospective Studies, Risk Factors, Stereotyped Behavior
Abstract

OBJECTIVE: As compared to the utility of early emerging social communicative risk markers for predicting a later diagnosis of autism spectrum disorder (ASD), less is known about the relevance of early patterns of restricted and repetitive behaviors. We examined patterns of stereotyped motor mannerisms and repetitive manipulation of objects in 12-month-olds at high and low risk for developing ASD, all of whom were assessed for ASD at 24 months.METHOD: Observational coding of repetitive object manipulation and stereotyped motor behaviors in digital recordings of the Communication and Symbolic Behavior Scales was conducted using the Repetitive and Stereotyped Movement Scales for 3 groups of 12-month-olds: low-risk infants (LR, n = 53); high-familial-risk infants who did not meet diagnostic criteria for ASD at 24 months (HR-negative, n = 75); and high-familial-risk infants who met diagnostic criteria for ASD at 24 months (HR-ASD, n = 30).RESULTS: The HR-ASD group showed significantly more stereotyped motor mannerisms than both the HR-negative group (p = .025) and the LR group (p = .001). The HR-ASD and HR-negative groups demonstrated statistically equivalent repetitive object manipulation scores (p = .431), and both groups showed significantly more repetitive object manipulation than the LR group (p < .040). Combining the motor and object stereotypy scores into a Repetitive and Stereotyped Movement Scales (RSMS) composite yielded a disorder-continuum effect such that each group was significantly different from one another (LR < HR-negative < HR-ASD).CONCLUSION: These results suggest that targeted assessment of repetitive behavior during infancy may augment early ASD identification efforts.

DOI10.1016/j.jaac.2014.08.004
Alternate JournalJ Am Acad Child Adolesc Psychiatry
PubMed ID25440311
PubMed Central IDPMC4254502
Grant ListHD055741-S1 / HD / NICHD NIH HHS / United States
T32 HD40127 / HD / NICHD NIH HHS / United States
P30 HD03110 / HD / NICHD NIH HHS / United States
T32 HD007376 / HD / NICHD NIH HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
P30 HD003110 / HD / NICHD NIH HHS / United States
5-T32-HD007376 / HD / NICHD NIH HHS / United States
T32 HD040127 / HD / NICHD NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States
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