Rate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.

TitleRate and Risk Factors Associated with Autism Spectrum Disorder in Congenital Diaphragmatic Hernia.
Publication TypeJournal Article
Year of Publication2018
AuthorsDanzer, E, Hoffman, C, D'Agostino, JAnn, Miller, JS, Waqar, LN, Gerdes, M, Bernbaum, JC, Rosenthal, H, Rintoul, NE, Herkert, LM, Peranteau, WH, Flake, AW, N Adzick, S, Hedrick, HL
JournalJ Autism Dev Disord
Date Published2018 Jan 30
ISSN1573-3432
Abstract

To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.

DOI10.1007/s10803-018-3472-6
Alternate JournalJ Autism Dev Disord
PubMed ID29383650