Prospective MEG biomarkers in ASD: pre-clinical evidence and clinical promise of electrophysiological signatures.

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TitleProspective MEG biomarkers in ASD: pre-clinical evidence and clinical promise of electrophysiological signatures.
Publication TypeJournal Article
Year of Publication2015
AuthorsPort, RG, Anwar, AR, Ku, M, Carlson, GC, Siegel, SJ, Roberts, TPL
JournalYale J Biol Med
Volume88
Issue1
Pagination25-36
Date Published2015 Mar
ISSN1551-4056
KeywordsAnimals, Autism Spectrum Disorder, Biomarkers, Disease Models, Animal, Electrophysiological Phenomena, Humans, Language, Magnetoencephalography
Abstract

Autism spectrum disorders (ASD) are characterized by social impairments and restricted/stereotyped behaviors and currently affect an estimated 1 in 68 children aged 8 years old. While there has been substantial recent focus on ASD in research, both the biological pathology and, perhaps consequently, a fully effective treatment have yet to be realized. What has remained throughout is the hypothesis that ASD has neurobiological underpinnings and the observation that both the phenotypic expression and likely the underlying etiology is highly heterogeneous. Given the neurodevelopmental basis of ASD, a biologically based marker (biomarker) could prove useful not only for diagnostic and prognostic purposes, but also for stratification and response indices for pharmaceutical development. In this review, we examine the current state of the field for MEG-related biomarkers in ASD. We describe several potential biomarkers (middle latency delays [M50/M100], mismatch negativity latency, gamma-band oscillatory activity), and investigate their relation to symptomology, core domains of dysfunction (e.g., language impairment), and putative biological underpinnings.

Alternate JournalYale J Biol Med
PubMed ID25745372
PubMed Central IDPMC4345535
Grant ListP30 HD026979 / HD / NICHD NIH HHS / United States
R01 DC008871 / DC / NIDCD NIH HHS / United States
P30HD026979 / HD / NICHD NIH HHS / United States
R01DC008871 / DC / NIDCD NIH HHS / United States
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