Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.

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TitlePositive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.
Publication TypeJournal Article
Year of Publication2017
AuthorsWalton, E, Hibar, DP, van Erp, TGM, Potkin, SG, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, van Haren, NEM, de Zwarte, SMC, Kahn, RS, Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Mørch-Johnsen, L, Faerden, A, Flyckt, L, Fatouros-Bergman, H, Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Preda, A, De Rossi, P, Piras, F, Banaj, N, Ciullo, V, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, DM, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, HC, Neilson, E, Calhoun, VD, Thompson, PM, Turner, JA, Ehrlich, S
Corporate AuthorsKarolinska Schizophrenia Project Consortium (KaSP)
JournalActa Psychiatr Scand
Volume135
Issue5
Pagination439-447
Date Published2017 May
ISSN1600-0447
KeywordsAdult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Temporal Lobe
Abstract

OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: β = -0.052; P = 0.021; right: β = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

DOI10.1111/acps.12718
Alternate JournalActa Psychiatr Scand
PubMed ID28369804
PubMed Central IDPMC5399182
Grant ListU24 RR021382 / RR / NCRR NIH HHS / United States
P41 EB015922 / EB / NIBIB NIH HHS / United States
T32 MH019112 / MH / NIMH NIH HHS / United States
P50 MH064045 / MH / NIMH NIH HHS / United States
R01 EB005846 / EB / NIBIB NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
R01 MH101111 / MH / NIMH NIH HHS / United States
P41 RR014075 / RR / NCRR NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
UL1 TR001414 / TR / NCATS NIH HHS / United States
U24 RR021992 / RR / NCRR NIH HHS / United States
K23 MH085096 / MH / NIMH NIH HHS / United States
U24 RR025736 / RR / NCRR NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
RC1 MH089257 / MH / NIMH NIH HHS / United States