Peak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder.

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TitlePeak Alpha Frequency and Thalamic Structure in Children with Typical Development and Autism Spectrum Disorder.
Publication TypeJournal Article
Year of Publication2021
AuthorsGreen, HL, Dipiero, M, Koppers, S, Berman, JI, Bloy, L, Liu, S, McBride, E, Ku, M, Blaskey, L, Kuschner, E, Airey, M, Kim, M, Konka, K, Roberts, TPL, J Edgar, C
JournalJ Autism Dev Disord
Date Published2021 Feb 25
ISSN1573-3432
Abstract

Associations between age, resting-state (RS) peak-alpha-frequency (PAF = frequency showing largest amplitude alpha activity), and thalamic volume (thalamus thought to modulate alpha activity) were examined to understand differences in RS alpha activity between children with autism spectrum disorder (ASD) and typically-developing children (TDC) noted in prior studies. RS MEG and structural-MRI data were obtained from 51 ASD and 70 TDC 6- to 18-year-old males. PAF and thalamic volume maturation were observed in TDC but not ASD. Although PAF was associated with right thalamic volume in TDC (R = 0.12, p = 0.01) but not ASD (R = 0.01, p = 0.35), this group difference was not large enough to reach significance. Findings thus showed unusual maturation of brain function and structure in ASD as well as an across-group thalamic contribution to alpha rhythms.

DOI10.1007/s10803-021-04926-9
Alternate JournalJ Autism Dev Disord
PubMed ID33629214
PubMed Central IDPMC8384980
Grant List5U54HD086984 / / National Institute of Child Health and Human Development /
R01 DC008871 / DC / NIDCD NIH HHS / United States
P30 HD026979 / HD / NICHD NIH HHS / United States
R21 MH098204 / MH / NIMH NIH HHS / United States
R01HD093776 / NH / NIH HHS / United States
R21 NS090192 / NS / NINDS NIH HHS / United States
R01DC008871 / NH / NIH HHS / United States
R01MH107506 / NH / NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
R01 HD093776 / HD / NICHD NIH HHS / United States
R01 MH107506 / MH / NIMH NIH HHS / United States
R21 MH110869 / MH / NIMH NIH HHS / United States
R21MH098204 / NH / NIH HHS / United States
R21 NS090192 / NH / NIH HHS / United States