Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion.

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TitlePatterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion.
Publication TypeJournal Article
Year of Publication2017
AuthorsSotiras, A, Toledo, JB, Gur, RE, Gur, RC, Satterthwaite, TD, Davatzikos, C
JournalProc Natl Acad Sci U S A
Volume114
Issue13
Pagination3527-3532
Date Published2017 03 28
ISSN1091-6490
Abstract

During adolescence, the human cortex undergoes substantial remodeling to support a rapid expansion of behavioral repertoire. Accurately quantifying these changes is a prerequisite for understanding normal brain development, as well as the neuropsychiatric disorders that emerge in this vulnerable period. Past accounts have demonstrated substantial regional heterogeneity in patterns of brain development, but frequently have been limited by small samples and analytics that do not evaluate complex multivariate imaging patterns. Capitalizing on recent advances in multivariate analysis methods, we used nonnegative matrix factorization (NMF) to uncover coordinated patterns of cortical development in a sample of 934 youths ages 8-20, who completed structural neuroimaging as part of the Philadelphia Neurodevelopmental Cohort. Patterns of structural covariance (PSCs) derived by NMF were highly reproducible over a range of resolutions, and differed markedly from common gyral-based structural atlases. Moreover, PSCs were largely symmetric and showed correspondence to specific large-scale functional networks. The level of correspondence was ordered according to their functional role and position in the evolutionary hierarchy, being high in lower-order visual and somatomotor networks and diminishing in higher-order association cortex. Furthermore, PSCs showed divergent developmental associations, with PSCs in higher-order association cortex networks showing greater changes with age than primary somatomotor and visual networks. Critically, such developmental changes within PSCs were significantly associated with the degree of evolutionary cortical expansion. Together, our findings delineate a set of structural brain networks that undergo coordinated cortical thinning during adolescence, which is in part governed by evolutionary novelty and functional specialization.

DOI10.1073/pnas.1620928114
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID28289224
PubMed Central IDPMC5380071
Grant ListP50 MH096891 / MH / NIMH NIH HHS / United States
R01 EB022573 / EB / NIBIB NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 MH112070 / MH / NIMH NIH HHS / United States
R01 MH101111 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
R01 NS042645 / NS / NINDS NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States