Neuroimaging of the Philadelphia neurodevelopmental cohort.

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TitleNeuroimaging of the Philadelphia neurodevelopmental cohort.
Publication TypeJournal Article
Year of Publication2014
AuthorsSatterthwaite, TD, Elliott, MA, Ruparel, K, Loughead, J, Prabhakaran, K, Calkins, ME, Hopson, R, Jackson, C, Keefe, J, Riley, M, Mentch, FD, Sleiman, P, Verma, R, Davatzikos, C, Hakonarson, H, Gur, RC, Gur, RE
JournalNeuroimage
Volume86
Pagination544-53
Date Published2014 Feb 01
ISSN1095-9572
KeywordsAdolescent, Adult, Brain, Child, Cognition, Cohort Studies, Female, Humans, Multimodal Imaging, Neuroimaging, Philadelphia, Research Design, Young Adult
Abstract

The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.

DOI10.1016/j.neuroimage.2013.07.064
Alternate JournalNeuroimage
PubMed ID23921101
PubMed Central IDPMC3947233
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
MH089924 / MH / NIMH NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
K08 MH079364 / MH / NIMH NIH HHS / United States
K08MH79364 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K23MH098130 / MH / NIMH NIH HHS / United States
MH089983 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States
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