Modular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth.

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TitleModular Segregation of Structural Brain Networks Supports the Development of Executive Function in Youth.
Publication TypeJournal Article
Year of Publication2017
AuthorsBaum, GL, Ciric, R, Roalf, DR, Betzel, RF, Moore, TM, Shinohara, RT, Kahn, AE, Vandekar, SN, Rupert, PE, Quarmley, M, Cook, PA, Elliott, MA, Ruparel, K, Gur, RE, Gur, RC, Bassett, DS, Satterthwaite, TD
JournalCurr Biol
Volume27
Issue11
Pagination1561-1572.e8
Date Published2017 Jun 05
ISSN1879-0445
KeywordsAdolescent, Age Factors, Child, Connectome, Diffusion Magnetic Resonance Imaging, Executive Function, Female, Humans, Male, Nerve Net, White Matter
Abstract

The human brain is organized into large-scale functional modules that have been shown to evolve in childhood and adolescence. However, it remains unknown whether the underlying white matter architecture is similarly refined during development, potentially allowing for improvements in executive function. In a sample of 882 participants (ages 8-22) who underwent diffusion imaging as part of the Philadelphia Neurodevelopmental Cohort, we demonstrate that structural network modules become more segregated with age, with weaker connections between modules and stronger connections within modules. Evolving modular topology facilitates global network efficiency and is driven by age-related strengthening of hub edges present both within and between modules. Critically, both modular segregation and network efficiency are associated with enhanced executive performance and mediate the improvement of executive functioning with age. Together, results delineate a process of structural network maturation that supports executive function in youth.

DOI10.1016/j.cub.2017.04.051
Alternate JournalCurr. Biol.
PubMed ID28552358
PubMed Central IDPMC5491213
Grant ListP50 MH096891 / MH / NIMH NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
R01 NS085211 / NS / NINDS NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States