Longitudinal patterns of repetitive behavior in toddlers with autism.

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TitleLongitudinal patterns of repetitive behavior in toddlers with autism.
Publication TypeJournal Article
Year of Publication2014
AuthorsWolff, JJ, Botteron, KN, Dager, SR, Elison, JT, Estes, AM, Gu, H, Hazlett, HC, Pandey, J, Paterson, SJ, Schultz, RT, Zwaigenbaum, L, Piven, J
Corporate AuthorsIBIS Network
JournalJ Child Psychol Psychiatry
Volume55
Issue8
Pagination945-53
Date Published2014 Aug
ISSN1469-7610
KeywordsAge Factors, Autistic Disorder, Case-Control Studies, Child Development, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Longitudinal Studies, Male, Stereotyped Behavior
Abstract

BACKGROUND: Recent evidence suggests that restricted and repetitive behaviors may differentiate children who develop autism spectrum disorder (ASD) by late infancy. How these core symptoms manifest early in life, particularly among infants at high risk for the disorder, is not well characterized.METHODS: Prospective, longitudinal parent-report data (Repetitive Behavior Scales-Revised) were collected for 190 high-risk toddlers and 60 low-risk controls from 12 to 24 months of age. Forty-one high-risk children were classified with ASD at age 2. Profiles of repetitive behavior were compared between groups using generalized estimating equations.RESULTS: Longitudinal profiles for children diagnosed with ASD differed significantly from high- and low-risk children without the disorder on all measures of repetitive behavior. High-risk toddlers without ASD were intermediate to low risk and ASD positive counterparts. Toddlers with ASD showed significantly higher rates of repetitive behavior across subtypes at the 12-month time point. Repetitive behaviors were significantly correlated with adaptive behavior and socialization scores among children with ASD at 24 months of age, but were largely unrelated to measures of general cognitive ability.CONCLUSIONS: These findings suggest that as early as 12 months of age, a broad range of repetitive behaviors are highly elevated in children who go on to develop ASD. While some degree of repetitive behavior is elemental to typical early development, the extent of these behaviors among children who develop ASD appears highly atypical.

DOI10.1111/jcpp.12207
Alternate JournalJ Child Psychol Psychiatry
PubMed ID24552513
PubMed Central IDPMC4107191
Grant ListR01-HD055741 / HD / NICHD NIH HHS / United States
HD055741-S1 / HD / NICHD NIH HHS / United States
P30-HD03110 / HD / NICHD NIH HHS / United States
P30 HD003110 / HD / NICHD NIH HHS / United States
K01-MN101653 / MN / OMHHE CDC HHS / United States
K01 MH101653 / MH / NIMH NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States