Localization of asymmetric brain function in emotion and depression.

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TitleLocalization of asymmetric brain function in emotion and depression.
Publication TypeJournal Article
Year of Publication2010
AuthorsHerrington, JD, Heller, W, Mohanty, A, Engels, AS, Banich, MT, Webb, AG, Miller, GA
JournalPsychophysiology
Volume47
Issue3
Pagination442-54
Date Published2010 May 01
ISSN1540-5958
KeywordsAffect, Amygdala, Brain, Data Interpretation, Statistical, Depression, Electroencephalography, Emotions, Female, Frontal Lobe, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Motivation, Neuropsychological Tests, Psychomotor Performance, Young Adult
Abstract

Although numerous EEG studies have shown that depression is associated with abnormal functional asymmetries in frontal cortex, fMRI and PET studies have largely failed to identify specific brain areas showing this effect. The present study tested the hypothesis that emotion processes are related to asymmetric patterns of fMRI activity, particularly within dorsolateral prefrontal cortex (DLPFC). Eleven depressed and 18 control participants identified the color in which pleasant, neutral, and unpleasant words were printed. Both groups showed a leftward lateralization for pleasant words in DLPFC. In a neighboring DLPFC area, the depression group showed more right-lateralized activation than controls, replicating EEG findings. These data confirm that emotional stimulus processing and trait depression are associated with asymmetric brain functions in distinct subregions of the DLPFC that may go undetected unless appropriate analytic procedures are used.

DOI10.1111/j.1469-8986.2009.00958.x
Alternate JournalPsychophysiology
PubMed ID20070577
PubMed Central IDPMC3086589
Grant ListR01 MH061358 / MH / NIMH NIH HHS / United States
R01 MH061358-05 / MH / NIMH NIH HHS / United States
R01 MH61358, / MH / NIMH NIH HHS / United States
T32 MH19554 / MH / NIMH NIH HHS / United States
P50 MH079485 / MH / NIMH NIH HHS / United States
R21 DA014111-01 / DA / NIDA NIH HHS / United States
T32 MH019554-11 / MH / NIMH NIH HHS / United States
P50 MH079485-02 / MH / NIMH NIH HHS / United States
R21 DA14111 / DA / NIDA NIH HHS / United States
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