Linked dimensions of psychopathology and connectivity in functional brain networks.

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TitleLinked dimensions of psychopathology and connectivity in functional brain networks.
Publication TypeJournal Article
Year of Publication2018
AuthorsXia, CHuchuan, Ma, Z, Ciric, R, Gu, S, Betzel, RF, Kaczkurkin, AN, Calkins, ME, Cook, PA, de La Garza, AGarcia, Vandekar, SN, Cui, Z, Moore, TM, Roalf, DR, Ruparel, K, Wolf, DH, Davatzikos, C, Gur, RC, Gur, RE, Shinohara, RT, Bassett, DS, Satterthwaite, TD
JournalNat Commun
Volume9
Issue1
Pagination3003
Date Published2018 08 01
ISSN2041-1723
KeywordsAdolescent, Adult, Brain, Child, Cohort Studies, Female, Humans, Male, Multivariate Analysis, Nerve Net, Psychopathology, Reproducibility of Results, Sex Characteristics, Young Adult
Abstract

Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical correlation analysis in a sample of 663 youths. This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology - mood, psychosis, fear, and externalizing behavior - are associated (r = 0.68-0.71) with distinct patterns of connectivity. Loss of network segregation between the default mode network and executive networks emerges as a common feature across all dimensions. Connectivity linked to mood and psychosis becomes more prominent with development, and sex differences are present for connectivity related to mood and fear. Critically, findings largely replicate in an independent dataset (n = 336). These results delineate connectivity-guided dimensions of psychopathology that cross clinical diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry.

DOI10.1038/s41467-018-05317-y
Alternate JournalNat Commun
PubMed ID30068943
PubMed Central IDPMC6070480
Grant ListR01MH107235 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
P50 MH096891 / MH / NIMH NIH HHS / United States
R01 EB022573 / EB / NIBIB NIH HHS / United States
R01 MH112847 / MH / NIMH NIH HHS / United States
R01MH101111 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01 NS099348 / NS / NINDS NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
P50MH096891 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01 DC009209 / DC / NIDCD NIH HHS / United States
K08 MH079364 / MH / NIMH NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
R01 MH101111 / MH / NIMH NIH HHS / United States
K08MH079364 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01EB022573 / / U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) / International
RC2 MH089924 / MH / NIMH NIH HHS / United States
R01 MH113550 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
R21MH106799 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01 HD086888 / HD / NICHD NIH HHS / United States
MH089983 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01MH112847 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
MH089924 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
U54 HD086984 / HD / NICHD NIH HHS / United States
K01MH102609 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01MH107703 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) / International
R01 NS085211 / NS / NINDS NIH HHS / United States
R01NS085211 / / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) / International
R01 MH107703 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States