|Title||Language delay aggregates in toddler siblings of children with autism spectrum disorder.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Marrus, N, Hall, LP, Paterson, SJ, Elison, JT, Wolff, JJ, Swanson, MR, Parish-Morris, J, Eggebrecht, AT, Pruett, JR, Hazlett, HC, Zwaigenbaum, L, Dager, S, Estes, AM, Schultz, RT, Botteron, KN, Piven, J, Constantino, JN|
|Corporate Authors||IBIS Network|
|Journal||J Neurodev Disord|
|Date Published||2018 Oct 22|
BACKGROUND: Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype.
METHODS: We implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique samples; an advantage of the latter was its sensitivity in quantifying early manifestations of language delay while accounting for covariates within a single large sample.
RESULTS: Meta-analysis showed that high-risk siblings without ASD (HR-noASD) were three to four times more likely to exhibit language delay versus low-risk siblings without ASD (LR-noASD) and had lower mean receptive and expressive language scores. Analyses of IBIS data corroborated that language delay, specifically receptive language delay, was more frequent in the HR-noASD (n = 235) versus LR-noASD group (n = 115). IBIS language scores were continuously and unimodally distributed, with a pathological shift towards decreased language function in HR-noASD siblings. The elevated inherited risk for ASD was associated with lower receptive and expressive language scores when controlling for sociodemographic factors. For receptive but not expressive language, the effect of risk group remained significant even when controlling for nonverbal cognition.
CONCLUSIONS: Greater frequency of language delay and a lower distribution of language scores in high-risk, unaffected toddler-aged siblings support decreased early language ability as an endophenotype for ASD, with a more pronounced effect for receptive versus expressive language. Further characterization of language development is warranted to refine genetic investigations of ASD and to elucidate factors influencing the progression of core autistic traits and related symptoms.
|Alternate Journal||J Neurodev Disord|
|PubMed Central ID||PMC6198516|
|Grant List||P30HD062171 / / National Institute of Child Health and Human Development / |
6020 / / Autism Speaks / United States
U54 HD087011 / HD / NICHD NIH HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
K99 MH108700 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
140209 / / Simons Foundation /
R01HD055741 / / National Institute of Child Health and Human Development /
K08 MH112891 / MH / NIMH NIH HHS / United States
K08MH112891 / / National Institute of Mental Health /
K01 MH103594 / MH / NIMH NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States