Imaging patterns of brain development and their relationship to cognition.

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TitleImaging patterns of brain development and their relationship to cognition.
Publication TypeJournal Article
Year of Publication2015
AuthorsErus, G, Battapady, H, Satterthwaite, TD, Hakonarson, H, Gur, RE, Davatzikos, C, Gur, RC
JournalCereb Cortex
Volume25
Issue6
Pagination1676-84
Date Published2015 Jun
ISSN1460-2199
KeywordsAdolescent, Aging, Brain, Brain Mapping, Child, Cognition, Cohort Studies, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Regression Analysis, Young Adult
Abstract

We present a brain development index (BDI) that concisely summarizes complex imaging patterns of structural brain maturation along a single dimension using a machine learning methodology. The brain was found to follow a remarkably consistent developmental trajectory in a sample of 621 subjects of ages 8-22 participating in the Philadelphia Neurodevelopmental Cohort, reflected by a cross-validated correlation coefficient between chronologic age and the BDI of r = 0.89. Critically, deviations from this trajectory related to cognitive performance. Specifically, subjects whose BDI was higher than their chronological age displayed significantly superior cognitive processing speed compared with subjects whose BDI was lower than their actual age. These results indicate that the multiparametric imaging patterns summarized by the BDI can accurately delineate trajectories of brain development and identify individuals with cognitive precocity or delay.

DOI10.1093/cercor/bht425
Alternate JournalCereb. Cortex
PubMed ID24421175
PubMed Central IDPMC4428302
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
MH089924 / MH / NIMH NIH HHS / United States
K23MH098130 / MH / NIMH NIH HHS / United States
MH089983 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
NIA-R01-14971 / / PHS HHS / United States
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