Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.

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TitleHomogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.
Publication TypeJournal Article
Year of Publication2017
AuthorsWiggins, LD, Tian, LH, Levy, SE, Rice, C, Lee, L-C, Schieve, L, Pandey, J, Daniels, J, Blaskey, L, Hepburn, S, Landa, R, Edmondson-Pretzel, R, Thompson, W
JournalJ Autism Dev Disord
Volume47
Issue11
Pagination3634-3645
Date Published2017 Nov
ISSN1573-3432
Abstract

The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.

DOI10.1007/s10803-017-3280-4
Alternate JournalJ Autism Dev Disord
PubMed ID28879490
PubMed Central IDPMC5848505
Grant ListU10DD000181 / / Centers for Disease Control and Prevention / United States
U10DD000184 / / Centers for Disease Control and Prevention / United States
U10 DD000180 / DD / NCBDD CDC HHS / United States
U10 DD000181 / DD / NCBDD CDC HHS / United States
U10DD000498 / / Centers for Disease Control and Prevention / United States
U10 DD000184 / DD / NCBDD CDC HHS / United States
U10DD000182 / / Centers for Disease Control and Prevention / United States
U01 DD001210 / DD / NCBDD CDC HHS / United States
U01 DD000498 / DD / NCBDD CDC HHS / United States
U01 DD001205 / DD / NCBDD CDC HHS / United States
CC999999 / / Intramural CDC HHS / United States
U10 DD000182 / DD / NCBDD CDC HHS / United States
U10DD000180 / / Centers for Disease Control and Prevention / United States
U10DD000183 / / Centers for Disease Control and Prevention / United States
U10 DD000183 / DD / NCBDD CDC HHS / United States
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