Functional maturation of the executive system during adolescence.

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TitleFunctional maturation of the executive system during adolescence.
Publication TypeJournal Article
Year of Publication2013
AuthorsSatterthwaite, TD, Wolf, DH, Erus, G, Ruparel, K, Elliott, MA, Gennatas, ED, Hopson, R, Jackson, C, Prabhakaran, K, Bilker, WB, Calkins, ME, Loughead, J, Smith, A, Roalf, DR, Hakonarson, H, Verma, R, Davatzikos, C, Gur, RC, Gur, RE
JournalJ Neurosci
Volume33
Issue41
Pagination16249-61
Date Published2013 Oct 09
ISSN1529-2401
KeywordsAdolescent, Brain, Brain Mapping, Child, Executive Function, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Young Adult
Abstract

Adolescence is characterized by rapid development of executive function. Working memory (WM) is a key element of executive function, but it is not known what brain changes during adolescence allow improved WM performance. Using a fractal n-back fMRI paradigm, we investigated brain responses to WM load in 951 human youths aged 8-22 years. Compared with more limited associations with age, WM performance was robustly associated with both executive network activation and deactivation of the default mode network. Multivariate patterns of brain activation predicted task performance with a high degree of accuracy, and also mediated the observed age-related improvements in WM performance. These results delineate a process of functional maturation of the executive system, and suggest that this process allows for the improvement of cognitive capability seen during adolescence.

DOI10.1523/JNEUROSCI.2345-13.2013
Alternate JournalJ. Neurosci.
PubMed ID24107956
PubMed Central IDPMC3792462
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
MH089924 / MH / NIMH NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
R01 MH101111 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
MH089983 / MH / NIMH NIH HHS / United States
K23MH085096 / MH / NIMH NIH HHS / United States
K23 MH085096 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States
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