Functional hypergraph uncovers novel covariant structures over neurodevelopment.

TitleFunctional hypergraph uncovers novel covariant structures over neurodevelopment.
Publication TypeJournal Article
Year of Publication2017
AuthorsGu, S, Yang, M, Medaglia, JD, Gur, RC, Gur, RE, Satterthwaite, TD, Bassett, DS
JournalHum Brain Mapp
Volume38
Issue8
Pagination3823-3835
Date Published2017 Aug
ISSN1097-0193
KeywordsAdolescent, Brain, Brain Mapping, Cerebrovascular Circulation, Child, Cohort Studies, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Rest, Young Adult
Abstract

Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas connected to one another in large-scale functional networks. Here, we apply a recently developed hypergraph approach that treats network connections (edges) rather than brain regions as the unit of interest, allowing us to describe functional network topology from a fundamentally different perspective. Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting-state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which respectively represent homogeneously connected, bipartite, and focal architectures. Cluster hyperedges show a strong resemblance to previously-described functional modules of the brain including somatomotor, visual, default mode, and salience systems. In contrast, star hyperedges represent highly localized subnetworks centered on a small set of regions, and are distributed across the entire cortex. Finally, bridge hyperedges link clusters and stars in a core-periphery organization. Notably, developmental changes within hyperedges are ordered in a similar core-periphery fashion, with the greatest developmental effects occurring in networked hyperedges within the functional core. Taken together, these results reveal a novel decomposition of the network organization of human brain, and further provide a new perspective on the role of local structures that emerge across neurodevelopment. Hum Brain Mapp 38:3823-3835, 2017. © 2017 Wiley Periodicals, Inc.

DOI10.1002/hbm.23631
Alternate JournalHum Brain Mapp
PubMed ID28493536
Grant ListR01 HD086888 / HD / NICHD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States