Functional Alignment with Anatomical Networks is Associated with Cognitive Flexibility.

TitleFunctional Alignment with Anatomical Networks is Associated with Cognitive Flexibility.
Publication TypeJournal Article
Year of Publication2018
AuthorsMedaglia, JD, Huang, W, Karuza, EA, Kelkar, A, Thompson-Schill, SL, Ribeiro, A, Bassett, DS
JournalNat Hum Behav
Volume2
Issue2
Pagination156-164
Date Published2018
ISSN2397-3374
Abstract

Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions by underlying white matter tracts. However, an integrated perspective regarding how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. To address this challenge, we applied emerging tools from graph signal processing to examine whether BOLD signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function correlate of human behavior.

DOI10.1038/s41562-017-0260-9
Alternate JournalNat Hum Behav
PubMed ID30498789
PubMed Central IDPMC6258039
Grant ListR01 NS099348 / NS / NINDS NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
R01 MH109520 / MH / NIMH NIH HHS / United States
DP5 OD021352 / OD / NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States