Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia.

Registration Now Open for

ADOS-2 Clinical Training Workshop

November 25-27. Click here for info!

TitleFrontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia.
Publication TypeJournal Article
Year of Publication2016
AuthorsChen, Y-H, Stone-Howell, B, J Edgar, C, Huang, M, Wootton, C, Hunter, MA, Lu, BY, Sadek, JR, Miller, GA, Cañive, JM
JournalBr J Psychiatry
Volume208
Issue2
Pagination160-7
Date Published2016 Feb
ISSN1472-1465
KeywordsAdult, Attention, Case-Control Studies, Cognition, Electroencephalography, Executive Function, Female, Frontal Lobe, Humans, Magnetoencephalography, Male, Middle Aged, Prognosis, Regression Analysis, Schizophrenia
Abstract

BACKGROUND: Increased temporal and frontal slow-wave delta (1-4 Hz) and theta (4-7 Hz) activities are the most consistent resting-state neural abnormalities reported in schizophrenia. The frontal lobe is associated with negative symptoms and cognitive abilities such as attention, with negative symptoms and impaired attention associated with poor functional capacity.AIMS: To establish whether frontal dysfunction, as indexed by slowing, would be associated with functional impairments.METHOD: Eyes-closed magnetoencephalography data were collected in 41 participants with schizophrenia and 37 healthy controls, and frequency-domain source imaging localised delta and theta activity.RESULTS: Elevated delta and theta activity in right frontal and right temporoparietal regions was observed in the schizophrenia v.CONTROL GROUP: In schizophrenia, right-frontal delta activity was uniquely associated with negative but not positive symptoms. In the full sample, increased right-frontal delta activity predicted poorer attention and functional capacity.CONCLUSIONS: Our findings suggest that treatment-associated decreases in slow-wave activity could be accompanied by improved functional outcome and thus better prognosis.

DOI10.1192/bjp.bp.114.156075
Alternate JournalBr J Psychiatry
PubMed ID26206861
PubMed Central IDPMC4837382
Grant ListK08 MH085100 / MH / NIMH NIH HHS / United States
R01 MH065304 / MH / NIMH NIH HHS / United States
R01 MH65304 / MH / NIMH NIH HHS / United States
Comments
Leave a Comment