The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future.

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Universal Screening for Autism in Toddlers

TitleThe Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future.
Publication TypeJournal Article
Year of Publication2013
AuthorsGottesman, O, Kuivaniemi, H, Tromp, G, W Faucett, A, Li, R, Manolio, TA, Sanderson, SC, Kannry, J, Zinberg, R, Basford, MA, Brilliant, M, Carey, DJ, Chisholm, RL, Chute, CG, Connolly, JJ, Crosslin, D, Denny, JC, Gallego, CJ, Haines, JL, Hakonarson, H, Harley, J, Jarvik, GP, Kohane, I, Kullo, IJ, Larson, EB, McCarty, C, Ritchie, MD, Roden, DM, Smith, ME, Böttinger, EP, Williams, MS
Corporate AuthorseMERGE Network
JournalGenet Med
Volume15
Issue10
Pagination761-71
Date Published2013 Oct
ISSN1530-0366
KeywordsElectronic Health Records, Genetic Research, Genome-Wide Association Study, Genomics, Genotype, Humans, National Human Genome Research Institute (U.S.), Phenotype, Precision Medicine, United States
Abstract

The Electronic Medical Records and Genomics Network is a National Human Genome Research Institute-funded consortium engaged in the development of methods and best practices for using the electronic medical record as a tool for genomic research. Now in its sixth year and second funding cycle, and comprising nine research groups and a coordinating center, the network has played a major role in validating the concept that clinical data derived from electronic medical records can be used successfully for genomic research. Current work is advancing knowledge in multiple disciplines at the intersection of genomics and health-care informatics, particularly for electronic phenotyping, genome-wide association studies, genomic medicine implementation, and the ethical and regulatory issues associated with genomics research and returning results to study participants. Here, we describe the evolution, accomplishments, opportunities, and challenges of the network from its inception as a five-group consortium focused on genotype-phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine.

DOI10.1038/gim.2013.72
Alternate JournalGenet. Med.
PubMed ID23743551
PubMed Central IDPMC3795928
Grant ListU01HG006379 / HG / NHGRI NIH HHS / United States
U01 HG006385 / HG / NHGRI NIH HHS / United States
U01HG004438 / HG / NHGRI NIH HHS / United States
U01 HG006375 / HG / NHGRI NIH HHS / United States
U01HG006375 / HG / NHGRI NIH HHS / United States
U01 HG004438 / HG / NHGRI NIH HHS / United States
U01HG004424 / HG / NHGRI NIH HHS / United States
UL1 TR000150 / TR / NCATS NIH HHS / United States
U01HG004610 / HG / NHGRI NIH HHS / United States
U01HG006830 / HG / NHGRI NIH HHS / United States
U01 HG006382 / HG / NHGRI NIH HHS / United States
U01HG006382 / HG / NHGRI NIH HHS / United States
U01 HG004603 / HG / NHGRI NIH HHS / United States
R01 LM009886 / LM / NLM NIH HHS / United States
U01HG04603 / HG / NHGRI NIH HHS / United States
U01 HG004424 / HG / NHGRI NIH HHS / United States
U01HG004609 / HG / NHGRI NIH HHS / United States
R01 DK088231 / DK / NIDDK NIH HHS / United States
U01 HG004609 / HG / NHGRI NIH HHS / United States
U01 HG006389 / HG / NHGRI NIH HHS / United States
U01 HG004599 / HG / NHGRI NIH HHS / United States
U01 HG006828 / HG / NHGRI NIH HHS / United States
U01HG006380 / HG / NHGRI NIH HHS / United States
R37 AI024717 / AI / NIAID NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
U01 HG006380 / HG / NHGRI NIH HHS / United States
U01HG006388 / HG / NHGRI NIH HHS / United States
U01HG004608 / HG / NHGRI NIH HHS / United States
U01 AG006781 / AG / NIA NIH HHS / United States
U01HG04599 / HG / NHGRI NIH HHS / United States
AG06781 / AG / NIA NIH HHS / United States
R01DK088231 / DK / NIDDK NIH HHS / United States
U01 HG006388 / HG / NHGRI NIH HHS / United States
U01 HG006378 / HG / NHGRI NIH HHS / United States
R01 GM105688 / GM / NIGMS NIH HHS / United States
U01 HG004610 / HG / NHGRI NIH HHS / United States
U01 HG006379 / HG / NHGRI NIH HHS / United States
U01HG006385 / HG / NHGRI NIH HHS / United States
U01HG006378 / HG / NHGRI NIH HHS / United States
P30DK072488 / DK / NIDDK NIH HHS / United States
U01 HG004608 / HG / NHGRI NIH HHS / United States
R01 DK091601 / DK / NIDDK NIH HHS / United States
R01DK091601 / DK / NIDDK NIH HHS / United States
U01HG006828 / HG / NHGRI NIH HHS / United States
U01HG006389 / HG / NHGRI NIH HHS / United States
U01 HG006830 / HG / NHGRI NIH HHS / United States
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