Effects of sleep deprivation and aging on long-term and remote memory in mice.

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TitleEffects of sleep deprivation and aging on long-term and remote memory in mice.
Publication TypeJournal Article
Year of Publication2015
AuthorsVecsey, CG, Park, AJ, Khatib, N, Abel, T
JournalLearn Mem
Volume22
Issue4
Pagination197-202
Date Published2015 Apr
ISSN1549-5485
KeywordsAging, Animals, Gene Expression, Male, Memory Disorders, Memory, Long-Term, Mice, Inbred C57BL, Neuropsychological Tests, Sleep Deprivation, Time Factors
Abstract

Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.

DOI10.1101/lm.036590.114
Alternate JournalLearn. Mem.
PubMed ID25776037
PubMed Central IDPMC4371173
Grant ListGM07517 / GM / NIGMS NIH HHS / United States
T32 HL007953 / HL / NHLBI NIH HHS / United States
HL07953 / HL / NHLBI NIH HHS / United States
R01 MH 099544 / MH / NIMH NIH HHS / United States
P50 AG 017628 / AG / NIA NIH HHS / United States
R01 MH099544 / MH / NIMH NIH HHS / United States
T32 GM007517 / GM / NIGMS NIH HHS / United States
P01 AG017628 / AG / NIA NIH HHS / United States
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