Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy.

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TitleDynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy.
Publication TypeJournal Article
Year of Publication2015
AuthorsKhambhati, AN, Davis, KA, Oommen, BS, Chen, SH, Lucas, TH, Litt, B, Bassett, DS
JournalPLoS Comput Biol
Volume11
Issue12
Paginatione1004608
Date Published2015 Dec
ISSN1553-7358
KeywordsAction Potentials, Computer Simulation, Epilepsy, Humans, Models, Neurological, Neocortex, Nerve Net, Neural Inhibition, Seizures, Synaptic Transmission
Abstract

The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a novel technique to objectively track seizure states from dynamic functional networks constructed from intracranial recordings. Each dynamical state captures unique patterns of network connections that indicate synchronized and desynchronized hubs of neural populations. Our approach suggests that seizures are generated when synchronous relationships near foci work in tandem with rapidly changing desynchronous relationships from the surrounding epileptic network. As seizures progress, topographical and geometrical changes in network connectivity strengthen and tighten synchronous connectivity near foci-a mechanism that may aid seizure termination. Collectively, our observations implicate distributed cortical structures in seizure generation, propagation and termination, and may have practical significance in determining which circuits to modulate with implantable devices.

DOI10.1371/journal.pcbi.1004608
Alternate JournalPLoS Comput. Biol.
PubMed ID26680762
PubMed Central IDPMC4682976
Grant ListR01 HD086888 / HD / NICHD NIH HHS / United States
1U24 NS 63930-01A1 / NS / NINDS NIH HHS / United States
R01-NS063039 / NS / NINDS NIH HHS / United States