Disrupted anatomic networks in the 22q11.2 deletion syndrome.

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TitleDisrupted anatomic networks in the 22q11.2 deletion syndrome.
Publication TypeJournal Article
Year of Publication2016
AuthorsJ Schmitt, E, Yi, J, Calkins, ME, Ruparel, K, Roalf, DR, Cassidy, A, Souders, MC, Satterthwaite, TD, McDonald-McGinn, DM, Zackai, EH, Gur, RC, Emanuel, BS, Gur, RE
JournalNeuroimage Clin
Volume12
Pagination420-8
Date Published2016
ISSN2213-1582
KeywordsAdult, Brain Mapping, DiGeorge Syndrome, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Young Adult
Abstract

The 22q11.2 deletion syndrome (22q11DS) is an uncommon genetic disorder with an increased risk of psychosis. Although the neural substrates of psychosis and schizophrenia are not well understood, aberrations in cortical networks represent intriguing potential mechanisms. Investigations of anatomic networks within 22q11DS are sparse. We investigated group differences in anatomic network structure in 48 individuals with 22q11DS and 370 typically developing controls by analyzing covariance patterns in cortical thickness among 68 regions of interest using graph theoretical models. Subjects with 22q11DS had less robust geographic organization relative to the control group, particularly in the occipital and parietal lobes. Multiple global graph theoretical statistics were decreased in 22q11DS. These results are consistent with prior studies demonstrating decreased connectivity in 22q11DS using other neuroimaging methodologies.

DOI10.1016/j.nicl.2016.08.020
Alternate JournalNeuroimage Clin
PubMed ID27622139
PubMed Central IDPMC5008050
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
U01 MH087626 / MH / NIMH NIH HHS / United States
T32 EB004311 / EB / NIBIB NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K01 ES026840 / ES / NIEHS NIH HHS / United States
U01 MH087636 / MH / NIMH NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States