Developmental increases in white matter network controllability support a growing diversity of brain dynamics.

TitleDevelopmental increases in white matter network controllability support a growing diversity of brain dynamics.
Publication TypeJournal Article
Year of Publication2017
AuthorsTang, E, Giusti, C, Baum, GL, Gu, S, Pollock, E, Kahn, AE, Roalf, DR, Moore, TM, Ruparel, K, Gur, RC, Gur, RE, Satterthwaite, TD, Bassett, DS
JournalNat Commun
Volume8
Issue1
Pagination1252
Date Published2017 Nov 01
ISSN2041-1723
Abstract

As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. Here we use a network representation of diffusion imaging data from 882 youth ages 8-22 to show that white matter connectivity becomes increasingly optimized for a diverse range of predicted dynamics in development. Notably, stable controllers in subcortical areas are negatively related to cognitive performance. Investigating structural mechanisms supporting these changes, we simulate network evolution with a set of growth rules. We find that all brain networks are structured in a manner highly optimized for network control, with distinct control mechanisms predicted in child vs. older youth. We demonstrate that our results cannot be explained by changes in network modularity. This work reveals a possible mechanism of human brain development that preferentially optimizes dynamic network control over static network architecture.

DOI10.1038/s41467-017-01254-4
Alternate JournalNat Commun
PubMed ID29093441
PubMed Central IDPMC5665937
Grant ListR01 NS099348 / NS / NINDS NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
R01 MH109520 / MH / NIMH NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States