A developmental fMRI study of self-regulatory control.

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TitleA developmental fMRI study of self-regulatory control.
Publication TypeJournal Article
Year of Publication2006
AuthorsMarsh, R, Zhu, H, Schultz, RT, Quackenbush, G, Royal, J, Skudlarski, P, Peterson, BS
JournalHum Brain Mapp
Volume27
Issue11
Pagination848-63
Date Published2006 Nov
ISSN1065-9471
KeywordsAdolescent, Adult, Age Factors, Brain, Brain Mapping, Child, Decision Making, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Inhibition (Psychology), Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Oxygen, Psychomotor Performance, Sex Factors
Abstract

We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of self-regulatory control across development in healthy individuals performing the Stroop interference task. Proper performance of the task requires the engagement of self-regulatory control to inhibit an automatized response (reading) in favor of another, less automatic response (color naming). Functional MRI scans were acquired from a sample of 70 healthy individuals ranging in age from 7 to 57 years. We measured task-related regional signal changes across the entire cerebrum and conducted correlation analyses to assess the associations of signal activation with age and with behavioral performance. The magnitude of fMRI signal change increased with age in the right inferolateral prefrontal cortex (Brodmann area [BA] 44/45) and right lenticular nucleus. Greater activation of the right inferolateral prefrontal cortex also accompanied better performance. Activity in the right frontostriatal systems increased with age and with better response inhibition, consistent with the known functions of frontostriatal circuits in self-regulatory control. Age-related deactivations in the mesial prefrontal cortex (BA 10), subgenual anterior cingulate cortex (BA 24), and posterior cingulate cortex (BA 31) likely represented the greater engagement of adults in self-monitoring and free associative thought processes during the easier baseline task, consistent with the improved performance on this task in adults compared with children. Although we cannot exclude the possibility that age-related changes in reading ability or in the strategies used to optimize task performance were responsible for our findings, the correlations of brain activation with performance suggest that changes in frontostriatal activity with age underlie the improvement in self-regulatory control that characterizes normal human development.

DOI10.1002/hbm.20225
Alternate JournalHum Brain Mapp
PubMed ID16421886
PubMed Central IDPMC2292452
Grant ListR01 MH068318-03 / MH / NIMH NIH HHS / United States
K02 MH074677-02 / MH / NIMH NIH HHS / United States
K02-74677 / / PHS HHS / United States
MH068318 / MH / NIMH NIH HHS / United States
R01 MH059139 / MH / NIMH NIH HHS / United States
K02 MH074677 / MH / NIMH NIH HHS / United States
MH01232 / MH / NIMH NIH HHS / United States
MH59139 / MH / NIMH NIH HHS / United States
R01 MH068318 / MH / NIMH NIH HHS / United States