Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment.

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TitleDelayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment.
Publication TypeJournal Article
Year of Publication2012
AuthorsRoberts, TPL, Heiken, K, Kahn, SY, Qasmieh, S, Blaskey, L, Solot, C, Parker, WAndrew, Verma, R, Edgar, JChristophe
JournalNeuroreport
Volume23
Issue8
Pagination463-8
Date Published2012 May 30
ISSN1473-558X
KeywordsAcoustic Stimulation, Adolescent, Auditory Perception, Chi-Square Distribution, Child, Contingent Negative Variation, Evoked Potentials, Auditory, Female, Humans, Language Development Disorders, Linear Models, Magnetoencephalography, Male, Reaction Time
Abstract

Recent studies show that electrophysiological markers of auditory processing such as the cortical 100 ms response (M100) and the mismatch field, derived from magnetoencephalography, might be used to identify children with autism spectrum disorders--M100 peak latency--and to stratify children with autism according to the degree of language impairment--mismatch field peak latency. The present study examined the latency of right superior temporal gyrus M100 and mismatch field in a cohort of children and young adolescents with specific language impairment (n=17), in comparison with age-matched and nonverbal intelligence quotient-matched typically developing controls (n=21). Neither group showed symptoms associated with autism. Although M100 latency (reflecting early auditory processing) did not distinguish controls from children with specific language impairment, the later 'change detection' mismatch field response was significantly delayed (by >50 ms) in the specific language impairment group. Linear discriminant analysis confirmed the role of mismatch field latency (92%) but not M100 latency (8%) in distinguishing groups. The present results lend support to the claim that a delayed M100 is specific to autism spectrum disorders (with relative independence of degree of language impairment) and that a delayed mismatch field reflects an abnormality more generally associated with language impairment, suggesting that mismatch field delay in the present specific language impairment group and previously reported in autistic children with language impairment may be indicative of a common neural system dysfunction.

DOI10.1097/WNR.0b013e32835202b6
Alternate JournalNeuroreport
PubMed ID22551948
PubMed Central IDPMC3345126
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
R01 MH092862 / MH / NIMH NIH HHS / United States
R01 DC008871-01 / DC / NIDCD NIH HHS / United States
R01 DC008871-02S1 / DC / NIDCD NIH HHS / United States
R01-MH092862 / MH / NIMH NIH HHS / United States
R01-DC008871 / DC / NIDCD NIH HHS / United States
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