Delayed Auditory Evoked Responses in Autism Spectrum Disorder across the Life Span.

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TitleDelayed Auditory Evoked Responses in Autism Spectrum Disorder across the Life Span.
Publication TypeJournal Article
Year of Publication2019
AuthorsMatsuzaki, J, Ku, M, Dipiero, M, Chiang, T, Saby, J, Blaskey, L, Kuschner, ES, Kim, M, Berman, JI, Bloy, L, Chen, Y-H, Dell, J, Liu, S, Brodkin, ES, Embick, D, Roberts, TPL
JournalDev Neurosci
Volume41
Issue3-4
Pagination223-233
Date Published2019
ISSN1421-9859
KeywordsAcoustic Stimulation, Adolescent, Adult, Auditory Cortex, Autism Spectrum Disorder, Child, Evoked Potentials, Auditory, Female, Humans, Longevity, Magnetoencephalography, Male, Young Adult
Abstract

The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of the neural correlates of auditory processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising from the left and right superior temporal gyrus during auditory presentation of tones to children/adolescents and adults with ASD as well as typically developing (TD) controls. One hundred and thirty-two participants (aged 6-42 years) were included into the final analyses (children/adolescents: TD, n = 36, 9.21 ± 1.6 years; ASD, n = 58, 10.07 ± 2.38 years; adults: TD, n = 19, 26.97 ± 1.29 years; ASD, n = 19, 23.80 ± 6.26 years). There were main effects of group on M50 and M100 latency (p < 0.001) over hemisphere and frequency. Delayed M50 and M100 latencies were found in participants with ASD compared to the TD group, and earlier M50 and M100 latencies were associated with increased age. Furthermore, there was a statistically significant association between language ability and both M50 and M100 latencies. Importantly, differences in M50 and M100 latencies between TD and ASD cohorts, often reported in children, persisted into adulthood, with no evidence supporting latency convergence.

DOI10.1159/000504960
Alternate JournalDev Neurosci
PubMed ID32007990
PubMed Central IDPMC7044064
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
R01 HD073258 / HD / NICHD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
UL1 RR024134 / RR / NCRR NIH HHS / United States