Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms.

New CAR Research Sheds Light on

 

Universal Screening for Autism in Toddlers

TitleConnectome-wide network analysis of youth with Psychosis-Spectrum symptoms.
Publication TypeJournal Article
Year of Publication2015
AuthorsSatterthwaite, TD, Vandekar, SN, Wolf, DH, Bassett, DS, Ruparel, K, Shehzad, Z, Craddock, RC, Shinohara, RT, Moore, TM, Gennatas, ED, Jackson, C, Roalf, DR, Milham, MP, Calkins, ME, Hakonarson, H, Gur, RC, Gur, RE
JournalMol Psychiatry
Volume20
Issue12
Pagination1508-15
Date Published2015 Dec
ISSN1476-5578
KeywordsAdolescent, Brain Mapping, Child, Connectome, Female, Humans, Magnetic Resonance Imaging, Male, Psychotic Disorders, Young Adult
Abstract

Adults with psychotic disorders have dysconnectivity in critical brain networks, including the default mode (DM) and the cingulo-opercular (CO) networks. However, it is unknown whether such deficits are present in youth with less severe symptoms. We conducted a multivariate connectome-wide association study examining dysconnectivity with resting state functional magnetic resonance imaging in a population-based cohort of 188 youths aged 8-22 years with psychosis-spectrum (PS) symptoms and 204 typically developing (TD) comparators. We found evidence for multi-focal dysconnectivity in PS youths, implicating the bilateral anterior cingulate, frontal pole, medial temporal lobe, opercular cortex and right orbitofrontal cortex. Follow-up seed-based and network-level analyses demonstrated that these results were driven by hyper-connectivity among DM regions and diminished connectivity among CO regions, as well as diminished coupling between frontal and DM regions. Collectively, these results provide novel evidence for functional dysconnectivity in PS youths, which show marked correspondence to abnormalities reported in adults with established psychotic disorders.

DOI10.1038/mp.2015.66
Alternate JournalMol. Psychiatry
PubMed ID26033240
PubMed Central IDPMC4651819
Grant ListP50 MH096891 / MH / NIMH NIH HHS / United States
K08MH079364 / MH / NIMH NIH HHS / United States
T32 MH065218 / MH / NIMH NIH HHS / United States
P50MH096891 / MH / NIMH NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
K08 MH079364 / MH / NIMH NIH HHS / United States
R01 MH101111 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K23MH098130 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
T32MH065218-11 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
R01 NS085211 / NS / NINDS NIH HHS / United States
R01MH101111 / MH / NIMH NIH HHS / United States
R01NS085211 / NS / NINDS NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States
K01MH102609 / MH / NIMH NIH HHS / United States
Comments
Leave a Comment