Cellular origins of auditory event-related potential deficits in Rett syndrome.

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TitleCellular origins of auditory event-related potential deficits in Rett syndrome.
Publication TypeJournal Article
Year of Publication2014
AuthorsGoffin, D, Brodkin, ES, Blendy, JA, Siegel, SJ, Zhou, Z
JournalNat Neurosci
Volume17
Issue6
Pagination804-6
Date Published2014 Jun
ISSN1546-1726
KeywordsAnimals, Evoked Potentials, Auditory, Interneurons, Male, Methyl-CpG-Binding Protein 2, Mice, Mice, Inbred C57BL, Mice, Transgenic, Prosencephalon, Rett Syndrome
Abstract

Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.

DOI10.1038/nn.3710
Alternate JournalNat. Neurosci.
PubMed ID24777420
PubMed Central IDPMC4038660
Grant ListR01 MH091850 / MH / NIMH NIH HHS / United States
R01 NS081054 / NS / NINDS NIH HHS / United States
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