Brain state expression and transitions are related to complex executive cognition in normative neurodevelopment.

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TitleBrain state expression and transitions are related to complex executive cognition in normative neurodevelopment.
Publication TypeJournal Article
Year of Publication2018
AuthorsMedaglia, JD, Satterthwaite, TD, Kelkar, A, Ciric, R, Moore, TM, Ruparel, K, Gur, RC, Gur, RE, Bassett, DS
JournalNeuroimage
Volume166
Pagination293-306
Date Published2018 Feb 01
ISSN1095-9572
Abstract

Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence and contribute to cognitive development is unknown. In a sample of 780 youth aged 8-22 yr (42.7% male) from the Philadelphia Neurodevelopment Cohort, we use a dynamic graph approach to extract activation states in BOLD fMRI data from 264 brain regions. We construct a graph in which each observation in time is a node and the similarity in brain states at two different times is an edge. Using this graphical approach, we identify two primary brain states reminiscent of intrinsic and task-evoked systems. We show that time spent in these two states is higher in older adolescents, as is the flexibility with which the brain switches between them. Increasing time spent in primary states and flexibility among states relates to increases in a complex executive accuracy factor score over adolescence. Flexibility is more positively associated with accuracy toward early adulthood. These findings suggest that brain state dynamics are associated with complex executive function across a critical period of adolescence.

DOI10.1016/j.neuroimage.2017.10.048
Alternate JournalNeuroimage
PubMed ID29126965
PubMed Central IDPMC5747984
Grant ListR01 MH112847 / MH / NIMH NIH HHS / United States
R01 NS099348 / NS / NINDS NIH HHS / United States
R01 MH107235 / MH / NIMH NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
R01 MH109520 / MH / NIMH NIH HHS / United States
DP5 OD021352 / OD / NIH HHS / United States
R01 DC014960 / DC / NIDCD NIH HHS / United States
R01 MH107703 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States