Brain hyperconnectivity in children with autism and its links to social deficits.

New CAR Research Sheds Light on

 

Universal Screening for Autism in Toddlers

TitleBrain hyperconnectivity in children with autism and its links to social deficits.
Publication TypeJournal Article
Year of Publication2013
AuthorsSupekar, K, Uddin, LQ, Khouzam, A, Phillips, J, Gaillard, WD, Kenworthy, LE, Yerys, BE, Vaidya, CJ, Menon, V
JournalCell Rep
Volume5
Issue3
Pagination738-47
Date Published2013 Nov 14
ISSN2211-1247
KeywordsAdolescent, Brain, Brain Mapping, Child, Child Development Disorders, Pervasive, Cohort Studies, Female, Humans, Magnetic Resonance Imaging, Male
Abstract

Autism spectrum disorder (ASD), a neurodevelopmental disorder affecting nearly 1 in 88 children, is thought to result from aberrant brain connectivity. Remarkably, there have been no systematic attempts to characterize whole-brain connectivity in children with ASD. Here, we use neuroimaging to show that there are more instances of greater functional connectivity in the brains of children with ASD in comparison to those of typically developing children. Hyperconnectivity in ASD was observed at the whole-brain and subsystems levels, across long- and short-range connections, and was associated with higher levels of fluctuations in regional brain signals. Brain hyperconnectivity predicted symptom severity in ASD, such that children with greater functional connectivity exhibited more severe social deficits. We replicated these findings in two additional independent cohorts, demonstrating again that at earlier ages, the brain of children with ASD is largely functionally hyperconnected in ways that contribute to social dysfunction. Our findings provide unique insights into brain mechanisms underlying childhood autism.

DOI10.1016/j.celrep.2013.10.001
Alternate JournalCell Rep
PubMed ID24210821
PubMed Central IDPMC3894787
Grant ListMH084164 / MH / NIMH NIH HHS / United States
K01MH092288 / MH / NIMH NIH HHS / United States
P30 HD040677 / HD / NICHD NIH HHS / United States
R01 HD047520 / HD / NICHD NIH HHS / United States
K01 MH092288 / MH / NIMH NIH HHS / United States
K23 MH086111 / MH / NIMH NIH HHS / United States
R01 MH084961 / MH / NIMH NIH HHS / United States
K23MH086111 / MH / NIMH NIH HHS / United States
R01 MH084164 / MH / NIMH NIH HHS / United States
HD059205 / HD / NICHD NIH HHS / United States
DC0111095 / DC / NIDCD NIH HHS / United States
HD047520 / HD / NICHD NIH HHS / United States
MH084961 / MH / NIMH NIH HHS / United States
P30HD40677 / HD / NICHD NIH HHS / United States
R21 DC011095 / DC / NIDCD NIH HHS / United States
R01 HD059205 / HD / NICHD NIH HHS / United States
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