Brain and cognitive reserve: Translation via network control theory.

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TitleBrain and cognitive reserve: Translation via network control theory.
Publication TypeJournal Article
Year of Publication2017
AuthorsMedaglia, JDominic, Pasqualetti, F, Hamilton, RH, Thompson-Schill, SL, Bassett, DS
JournalNeurosci Biobehav Rev
Date Published2017 Apr
KeywordsBrain, Cognitive Reserve, Connectome, Humans, Nerve Net

Traditional approaches to understanding the brain's resilience to neuropathology have identified neurophysiological variables, often described as brain or cognitive "reserve," associated with better outcomes. However, mechanisms of function and resilience in large-scale brain networks remain poorly understood. Dynamic network theory may provide a basis for substantive advances in understanding functional resilience in the human brain. In this perspective, we describe recent theoretical approaches from network control theory as a framework for investigating network level mechanisms underlying cognitive function and the dynamics of neuroplasticity in the human brain. We describe the theoretical opportunities offered by the application of network control theory at the level of the human connectome to understand cognitive resilience and inform translational intervention.

Alternate JournalNeurosci Biobehav Rev
PubMed ID28104411
PubMed Central IDPMC5359115
Grant ListT32 HD071844 / HD / NICHD NIH HHS / United States
R01 NS099348 / NS / NINDS NIH HHS / United States
R01 DC009209 / DC / NIDCD NIH HHS / United States
R21 MH106799 / MH / NIMH NIH HHS / United States
R01 HD086888 / HD / NICHD NIH HHS / United States
DP5 OD021352 / OD / NIH HHS / United States