Bidirectional communication between amygdala and fusiform gyrus during facial recognition.

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TitleBidirectional communication between amygdala and fusiform gyrus during facial recognition.
Publication TypeJournal Article
Year of Publication2011
AuthorsHerrington, JD, Taylor, JM, Grupe, DW, Curby, KM, Schultz, RT
JournalNeuroimage
Volume56
Issue4
Pagination2348-55
Date Published2011 Jun 15
ISSN1095-9572
KeywordsAmygdala, Brain Mapping, Face, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Pattern Recognition, Visual, Recognition (Psychology), Temporal Lobe, Young Adult
Abstract

Decades of research have documented the specialization of fusiform gyrus (FG) for facial information processes. Recent theories indicate that FG activity is shaped by input from amygdala, but effective connectivity from amygdala to FG remains undocumented. In this fMRI study, 39 participants completed a face recognition task. 11 participants underwent the same experiment approximately four months later. Robust face-selective activation of FG, amygdala, and lateral occipital cortex were observed. Dynamic causal modeling and Bayesian Model Selection (BMS) were used to test the intrinsic connections between these structures, and their modulation by face perception. BMS results strongly favored a dynamic causal model with bidirectional, face-modulated amygdala-FG connections. However, the right hemisphere connections diminished at time 2, with the face modulation parameter no longer surviving Bonferroni correction. These findings suggest that amygdala strongly influences FG function during face perception, and that this influence is shaped by experience and stimulus salience.

DOI10.1016/j.neuroimage.2011.03.072
Alternate JournalNeuroimage
PubMed ID21497657
PubMed Central IDPMC3137553
Grant ListR01 MH073084 / MH / NIMH NIH HHS / United States
R01 MH073084-01 / MH / NIMH NIH HHS / United States
R01MH073084 / MH / NIMH NIH HHS / United States
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