Altered reward system reactivity for personalized circumscribed interests in autism.

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TitleAltered reward system reactivity for personalized circumscribed interests in autism.
Publication TypeJournal Article
Year of Publication2018
AuthorsKohls, G, Antezana, L, Mosner, MG, Schultz, RT, Yerys, BE
JournalMol Autism
Volume9
Pagination9
Date Published2018
ISSN2040-2392
KeywordsAdolescent, Autistic Disorder, Brain, Case-Control Studies, Child, Female, Humans, Magnetic Resonance Imaging, Male, Motivation, Reward, Social Behavior, Stereotyped Behavior
Abstract

Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs).Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research.Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment.Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families.

DOI10.1186/s13229-018-0195-7
Alternate JournalMol Autism
PubMed ID29423135
PubMed Central IDPMC5791309
Grant ListP30 HD026979 / HD / NICHD NIH HHS / United States
K23 MH086111 / MH / NIMH NIH HHS / United States
R21 MH092615 / MH / NIMH NIH HHS / United States
RC1 MH088791 / MH / NIMH NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States