Altered corpus callosum morphology associated with autism over the first 2 years of life.

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TitleAltered corpus callosum morphology associated with autism over the first 2 years of life.
Publication TypeJournal Article
Year of Publication2015
AuthorsWolff, JJ, Gerig, G, Lewis, JD, Soda, T, Styner, MA, Vachet, C, Botteron, KN, Elison, JT, Dager, SR, Estes, AM, Hazlett, HC, Schultz, RT, Zwaigenbaum, L, Piven, J
Corporate AuthorsIBIS Network
IssuePt 7
Date Published2015 Jul
KeywordsAdolescent, Child, Child Development Disorders, Pervasive, Child, Preschool, Corpus Callosum, Cross-Sectional Studies, Female, Humans, Image Interpretation, Computer-Assisted, Infant, Longitudinal Studies, Magnetic Resonance Imaging, Male, Young Adult

Numerous brain imaging studies indicate that the corpus callosum is smaller in older children and adults with autism spectrum disorder. However, there are no published studies examining the morphological development of this connective pathway in infants at-risk for the disorder. Magnetic resonance imaging data were collected from 270 infants at high familial risk for autism spectrum disorder and 108 low-risk controls at 6, 12 and 24 months of age, with 83% of infants contributing two or more data points. Fifty-seven children met criteria for ASD based on clinical-best estimate diagnosis at age 2 years. Corpora callosa were measured for area, length and thickness by automated segmentation. We found significantly increased corpus callosum area and thickness in children with autism spectrum disorder starting at 6 months of age. These differences were particularly robust in the anterior corpus callosum at the 6 and 12 month time points. Regression analysis indicated that radial diffusivity in this region, measured by diffusion tensor imaging, inversely predicted thickness. Measures of area and thickness in the first year of life were correlated with repetitive behaviours at age 2 years. In contrast to work from older children and adults, our findings suggest that the corpus callosum may be larger in infants who go on to develop autism spectrum disorder. This result was apparent with or without adjustment for total brain volume. Although we did not see a significant interaction between group and age, cross-sectional data indicated that area and thickness differences diminish by age 2 years. Regression data incorporating diffusion tensor imaging suggest that microstructural properties of callosal white matter, which includes myelination and axon composition, may explain group differences in morphology.

Alternate JournalBrain
PubMed ID25937563
PubMed Central IDPMC4492413
Grant ListU54 HD083091 / HD / NICHD NIH HHS / United States
U54-079124 / / PHS HHS / United States
P30-03110 / / PHS HHS / United States
T32 GM007753 / GM / NIGMS NIH HHS / United States
055741-S1 / / PHS HHS / United States
U54-EB005149 / EB / NIBIB NIH HHS / United States
K01-101653 / / PHS HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
R01-055741 / / PHS HHS / United States
K01 MH101653 / MH / NIMH NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States