Adverse effects of heavy prenatal maternal smoking on attentional control in children with ADHD.

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TitleAdverse effects of heavy prenatal maternal smoking on attentional control in children with ADHD.
Publication TypeJournal Article
Year of Publication2011
AuthorsMotlagh, MG, Sukhodolsky, DG, Landeros-Weisenberger, A, Katsovich, L, Thompson, N, Scahill, L, King, RA, Peterson, BS, Schultz, RT, Leckman, JF
JournalJ Atten Disord
Volume15
Issue7
Pagination593-603
Date Published2011 Oct
ISSN1557-1246
KeywordsAdolescent, Attention, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Mothers, Neuropsychological Tests, Pregnancy, Prenatal Exposure Delayed Effects, Reaction Time, Risk Factors, Smoking
Abstract

OBJECTIVE: Exposure to heavy maternal cigarette smoking in pregnancy and severe maternal psychosocial stress during pregnancy appear to be important risk factors for the development of ADHD. This study aimed to determine whether these perinatal risk factors were associated with neuropsychological deficits commonly seen in ADHD.METHOD: We examined the effect of these two risk factors on measures of attentional control, motor inhibition, visual-motor integration, and fine motor coordination in a group of 81 children with ADHD, aged from 8 to 18 years. The neuropsychological battery included the Connors' Continuous Performance Test (CPT), the Stroop Color-Word Interference Test, the Beery Visual-Motor Integration Test, and the Purdue Pegboard Test.RESULTS: Heavy maternal smoking during pregnancy was associated with slower reaction times (p < .002), and reaction time variability (p < .007) on the CPT.CONCLUSIONS: This study suggests a persistent negative effect of heavy prenatal maternal smoking on attentional control in children with ADHD. Future studies should examine the neurobiological basis and determine the degree to which inherited genetic susceptibility factors contribute to this finding.

DOI10.1177/1087054710374576
Alternate JournalJ Atten Disord
PubMed ID20616372
PubMed Central IDPMC3974616
Grant ListR01 MH066187 / MH / NIMH NIH HHS / United States
K02 MH074677-01 / MH / NIMH NIH HHS / United States
R01 MH59139 / MH / NIMH NIH HHS / United States
P01MH049351 / MH / NIMH NIH HHS / United States
K05 MH076273 / MH / NIMH NIH HHS / United States
P01 MH049351 / MH / NIMH NIH HHS / United States
RR00125 / RR / NCRR NIH HHS / United States
R01 MH059139 / MH / NIMH NIH HHS / United States
K02 MH074677 / MH / NIMH NIH HHS / United States
MH066187 / MH / NIMH NIH HHS / United States
M01 RR000125 / RR / NCRR NIH HHS / United States