Activation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior.

New CAR Research Sheds Light on

 

Universal Screening for Autism in Toddlers

TitleActivation of basolateral amygdala in juvenile C57BL/6J mice during social approach behavior.
Publication TypeJournal Article
Year of Publication2016
AuthorsFerri, SL, Kreibich, AS, Torre, M, Piccoli, CT, Dow, H, Pallathra, AA, Li, H, Bilker, WB, Gur, RC, Abel, T, Brodkin, ES
JournalNeuroscience
Volume335
Pagination184-94
Date Published2016 Oct 29
ISSN1873-7544
KeywordsAnimals, Autism Spectrum Disorder, Basolateral Nuclear Complex, Behavior, Animal, Brain, Disease Models, Animal, Male, Mice, Inbred C57BL, Phenotype, Social Behavior
Abstract

There is a strong need to better understand the neurobiology of juvenile sociability (tendency to seek social interaction), a phenotype of central relevance to autism spectrum disorders (ASD). Although numerous genetic mouse models of ASD showing reduced sociability have been reported, and certain brain regions, such as the amygdala, have been implicated in sociability, there has been little emphasis on delineating brain structures and circuits activated during social interactions in the critical juvenile period of the mouse strain that serves as the most common genetic background for these models-the highly sociable C57BL/6J (B6) strain. We measured expression of the immediate early genes Fos and Egr-1 to map activation of brain regions following the Social Approach Test (SAT) in juvenile male B6 mice. We hypothesized that juvenile B6 mice would show activation of the amygdala during social interactions. The basolateral amygdala (BLA) was activated by social exposure in highly sociable, 4-week-old B6 mice. In light of these data, and the many lines of evidence indicating alteration of amygdala circuits in human ASD, future studies are warranted to assess structural and functional alterations in the BLA, particularly at BLA synapses, in various mouse models of ASD.

DOI10.1016/j.neuroscience.2016.08.006
Alternate JournalNeuroscience
PubMed ID27520082
PubMed Central IDPMC5056014
Grant ListP50 MH096891 / MH / NIMH NIH HHS / United States
R01 MH080718 / MH / NIMH NIH HHS / United States
T32 NS007413 / NS / NINDS NIH HHS / United States
/ / Wellcome Trust / United Kingdom
R21 NS077413 / NS / NINDS NIH HHS / United States