Title | Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Pruett, JR, Kandala, S, Hoertel, S, Snyder, AZ, Elison, JT, Nishino, T, Feczko, E, Dosenbach, NUF, Nardos, B, Power, JD, Adeyemo, B, Botteron, KN, Mckinstry, RC, Evans, AC, Hazlett, HC, Dager, SR, Paterson, S, Schultz, RT, D Collins, L, Fonov, VS, Styner, M, Gerig, G, Das, S, Kostopoulos, P, Constantino, JN, Estes, AM, Petersen, SE, Schlaggar, BL, Piven, J |
Corporate Authors | IBIS Network |
Journal | Dev Cogn Neurosci |
Volume | 12 |
Pagination | 123-33 |
Date Published | 2015 Apr |
ISSN | 1878-9307 |
Keywords | Age Factors, Brain, Child Development Disorders, Pervasive, Female, Humans, Infant, Longitudinal Studies, Magnetic Resonance Imaging, Male, Risk Assessment |
Abstract | Human large-scale functional brain networks are hypothesized to undergo significant changes over development. Little is known about these functional architectural changes, particularly during the second half of the first year of life. We used multivariate pattern classification of resting-state functional connectivity magnetic resonance imaging (fcMRI) data obtained in an on-going, multi-site, longitudinal study of brain and behavioral development to explore whether fcMRI data contained information sufficient to classify infant age. Analyses carefully account for the effects of fcMRI motion artifact. Support vector machines (SVMs) classified 6 versus 12 month-old infants (128 datasets) above chance based on fcMRI data alone. Results demonstrate significant changes in measures of brain functional organization that coincide with a special period of dramatic change in infant motor, cognitive, and social development. Explorations of the most different correlations used for SVM lead to two different interpretations about functional connections that support 6 versus 12-month age categorization. |
DOI | 10.1016/j.dcn.2015.01.003 |
Alternate Journal | Dev Cogn Neurosci |
PubMed ID | 25704288 |
PubMed Central ID | PMC4385423 |
Grant List | U54 HD083091 / HD / NICHD NIH HHS / United States R01 MH093510 / MH / NIMH NIH HHS / United States K12 EY016336 / EY / NEI NIH HHS / United States U54 HD079124 / HD / NICHD NIH HHS / United States P30 NS048056 / NS / NINDS NIH HHS / United States UL1 TR000448 / TR / NCATS NIH HHS / United States U54 HD086984 / HD / NICHD NIH HHS / United States R01 HD055741 / HD / NICHD NIH HHS / United States |
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