Accurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data.

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TitleAccurate age classification of 6 and 12 month-old infants based on resting-state functional connectivity magnetic resonance imaging data.
Publication TypeJournal Article
Year of Publication2015
AuthorsPruett, JR, Kandala, S, Hoertel, S, Snyder, AZ, Elison, JT, Nishino, T, Feczko, E, Dosenbach, NUF, Nardos, B, Power, JD, Adeyemo, B, Botteron, KN, Mckinstry, RC, Evans, AC, Hazlett, HC, Dager, SR, Paterson, S, Schultz, RT, D Collins, L, Fonov, VS, Styner, M, Gerig, G, Das, S, Kostopoulos, P, Constantino, JN, Estes, AM, Petersen, SE, Schlaggar, BL, Piven, J
Corporate AuthorsIBIS Network
JournalDev Cogn Neurosci
Volume12
Pagination123-33
Date Published2015 Apr
ISSN1878-9307
KeywordsAge Factors, Brain, Child Development Disorders, Pervasive, Female, Humans, Infant, Longitudinal Studies, Magnetic Resonance Imaging, Male, Risk Assessment
Abstract

Human large-scale functional brain networks are hypothesized to undergo significant changes over development. Little is known about these functional architectural changes, particularly during the second half of the first year of life. We used multivariate pattern classification of resting-state functional connectivity magnetic resonance imaging (fcMRI) data obtained in an on-going, multi-site, longitudinal study of brain and behavioral development to explore whether fcMRI data contained information sufficient to classify infant age. Analyses carefully account for the effects of fcMRI motion artifact. Support vector machines (SVMs) classified 6 versus 12 month-old infants (128 datasets) above chance based on fcMRI data alone. Results demonstrate significant changes in measures of brain functional organization that coincide with a special period of dramatic change in infant motor, cognitive, and social development. Explorations of the most different correlations used for SVM lead to two different interpretations about functional connections that support 6 versus 12-month age categorization.

DOI10.1016/j.dcn.2015.01.003
Alternate JournalDev Cogn Neurosci
PubMed ID25704288
PubMed Central IDPMC4385423
Grant ListU54 HD083091 / HD / NICHD NIH HHS / United States
R01 MH093510 / MH / NIMH NIH HHS / United States
K12 EY016336 / EY / NEI NIH HHS / United States
U54 HD079124 / HD / NICHD NIH HHS / United States
P30 NS048056 / NS / NINDS NIH HHS / United States
U54 HD086984 / HD / NICHD NIH HHS / United States
R01 HD055741 / HD / NICHD NIH HHS / United States
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