Absence of M100 source asymmetry in autism associated with language functioning.

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TitleAbsence of M100 source asymmetry in autism associated with language functioning.
Publication TypeJournal Article
Year of Publication2009
AuthorsSchmidt, GL, Rey, MM, Cardy, JEOram, Roberts, TPL
JournalNeuroreport
Volume20
Issue11
Pagination1037-41
Date Published2009 Jul 15
ISSN1473-558X
KeywordsAcoustic Stimulation, Adolescent, Adult, Aging, Auditory Cortex, Auditory Perception, Autistic Disorder, Brain, Brain Mapping, Child, Evoked Potentials, Auditory, Female, Functional Laterality, Humans, Language, Language Tests, Magnetoencephalography, Male, Middle Aged, Young Adult
Abstract

Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with language functioning. Evoked neural activity to a 1 kHz tone was recorded using whole-cortex 151-channel magnetoencephalography in three groups of individuals. A single-dipole model identified the M100 generator in auditory cortex in each hemisphere. Healthy adults and control children displayed the expected right-sided M100 anteriority, whereas children with autism showed no such asymmetry. An association was found between language functioning and the degree of asymmetry across the two groups of children, suggesting a possible relationship between functional-structural asymmetry and language ability.

DOI10.1097/WNR.0b013e32832e0ca7
Alternate JournalNeuroreport
PubMed ID19491710
PubMed Central IDPMC2795634
Grant ListR01 DC008871 / DC / NIDCD NIH HHS / United States
R01 DC008871-01 / DC / NIDCD NIH HHS / United States
T32 NS007413 / NS / NINDS NIH HHS / United States
T32NS007413 / NS / NINDS NIH HHS / United States
NIH-R01 DC008871 / DC / NIDCD NIH HHS / United States
T32 NS007413-12 / NS / NINDS NIH HHS / United States
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