Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome.

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TitleAberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome.
Publication TypeJournal Article
Year of Publication2015
AuthorsJ Schmitt, E, Vandekar, S, Yi, J, Calkins, ME, Ruparel, K, Roalf, DR, Whinna, D, Souders, MC, Satterwaite, TD, Prabhakaran, K, McDonald-McGinn, DM, Zackai, EH, Gur, RC, Emanuel, BS, Gur, RE
JournalBiol Psychiatry
Volume78
Issue2
Pagination135-43
Date Published2015 Jul 15
ISSN1873-2402
Keywords22q11 Deletion Syndrome, Adolescent, Adult, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Young Adult
Abstract

BACKGROUND: There is increased risk of developing psychosis in 22q11.2 deletion syndrome (22q11DS). Although this condition is associated with morphologic brain abnormalities, simultaneous examination of multiple high-resolution measures of cortical structure has not been performed.METHODS: Fifty-three patients with 22q11DS, 30 with psychotic symptoms, were compared with demographically matched nondeleted youths: 53 typically developing and 53 with psychotic symptoms. High-resolution magnetic resonance imaging measures of cerebral volume, cortical thickness, surface area, and an index of local gyrification were obtained and compared between groups.RESULTS: Patients with 22q11DS demonstrated global increases in cortical thickness associated with reductions in surface area, reduced index of local gyrification, and lower cerebral volumes relative to typically developing controls. Findings were principally in the frontal lobe, superior parietal lobes, and in the paramedian cerebral cortex. Focally decreased thickness was seen in the superior temporal gyrus and posterior cingulate cortex in 22q11DS relative to nondeleted groups. Patterns between nondeleted participants with psychotic symptoms and 22q11DS were similar but with important differences in several regions implicated in schizophrenia. Post hoc analysis suggested that like the 22q11DS group, cortical thickness in nondeleted individuals with psychotic symptoms differed from typically developing controls in the superior frontal gyrus and superior temporal gyrus, regions previously linked to schizophrenia.CONCLUSIONS: Simultaneous examination of multiple measures of cerebral architecture demonstrates that differences in 22q11DS localize to regions of the frontal, superior parietal, superior temporal, and paramidline cerebral cortex. The overlapping patterns between nondeleted participants with psychotic symptoms and 22q11DS suggest partially shared neuroanatomic substrates.

DOI10.1016/j.biopsych.2014.10.025
Alternate JournalBiol. Psychiatry
PubMed ID25555483
PubMed Central IDPMC4446247
Grant ListT32 MH019112 / MH / NIMH NIH HHS / United States
K08MH079364 / MH / NIMH NIH HHS / United States
T32 MH065218 / MH / NIMH NIH HHS / United States
U01 MH087626 / MH / NIMH NIH HHS / United States
T32 EB004311 / EB / NIBIB NIH HHS / United States
MH089924 / MH / NIMH NIH HHS / United States
K23 MH098130 / MH / NIMH NIH HHS / United States
MH019112 / MH / NIMH NIH HHS / United States
K08 MH079364 / MH / NIMH NIH HHS / United States
RC2 MH089924 / MH / NIMH NIH HHS / United States
K23MH098130 / MH / NIMH NIH HHS / United States
MH087626 / MH / NIMH NIH HHS / United States
K01 MH102609 / MH / NIMH NIH HHS / United States
EB004311 / EB / NIBIB NIH HHS / United States
MH089983 / MH / NIMH NIH HHS / United States
MH087636 / MH / NIMH NIH HHS / United States
U01 MH087636 / MH / NIMH NIH HHS / United States
RC2 MH089983 / MH / NIMH NIH HHS / United States