I am Professor of Biology and Director of the Biological Basis of Behavior Program at the University of Pennsylvania. My primary research interest is the study of mouse behavioral genetics. We are particularly interested in using mouse models to identify novel therapeutic approaches to treat cognitive deficits and behavioral alterations in mouse models of autism and other psychiatric disorders.
I am also active within the autism research community and serve as member of the Clinical Trials Network Steering Committee of Autism Speaks. In the past, I have been a member of the Board of Directors and Scientific Review Council of Cure Autism Now and the Scientific Advisory Committee of Autism Speaks.
Sample of Significant Publications
Abel T, Nguyen PV. Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase. Progress in Brain Research. 2008. 169: 97-115.
Abel T, Zukin RS. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Current Opinion in Pharmacology. Feb 2008. 8(1): 57-64.
Bucan M, Abel T. The mouse: Genetics meets behavior. Nature Reviews Genetics. 2002. 3: 114-123.
Lattal KM, Abel T. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proceedings of the National Academy of Sciences. 2004. 101: 4667-4672.
Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CREB-binding protein-dependent transcriptional activation. Journal of Neuroscience. 2007. 27: 6128-6140.